[Antibodies and antigens and lymphocytes, oh my! What exactly do these microscopic medical marvels have to do with vaccines?. Imagine courtesy of the Encyclopaedia Britannica.]
In the second part of our series on vaccines, I’ll be giving a brief overview of how the immune system works and how vaccines help train it to fight disease! Keep in mind that this information has been simplified somewhat for easier understanding (on both my part and yours, I’m certainly no immunologist!); the immune system is a wildly complex and intense part of any living being! But as primers go, this should help further your understanding 🙂 Missed the first part of this series? Check out Part One for a basic vaccine overview.
Dear Clients;
How much do you know about how vaccines work? Probably you know the basic concept — that they protect your pet from certain diseases by teaching the immune system to fight them — but that’s just scraping the surface. A lot of vaccine misinformation is based on incorrect ideas of how and why vaccines work. In order to understand why vaccines are so important (and why giving them properly is key!), let’s dive a little further into the science behind them.
When your pet is infected with a virus or bacteria, the immune system is able to identify it as a new foreign (and dangerous!) by ‘reading’ special molecules on the microbe called antigens. White blood cells called macrophages engulf and destroy these foreign microbes but save the antigens and ‘show’ them to the immune system. In response, the immune system springs into action! White blood cells called B lymphocytes begin to create and release antibodies, molecules which bind to a microbe’s antigens. These antibodies prevent the microbe from functioning and also act as a signal for other white blood cells to come and destroy the microbe. Sometimes, the antibody response alone is enough to eliminate the threat. If not, other white blood cells called T lymphocytes will help. ‘Offensive’ T lymphocytes (killer T cells) find and destroy your pet’s infected cells, while ‘defensive’ T lymphocytes (helper T cells) help to coordinate the body’s immune response with chemical signals, helping to direct both B cells and killer T cells. The immune response can take up to several days to reach peak efficiency. Once the virus or bacteria has been eliminated from your pet’s body, some of these white blood cells become memory cells. If the same virus or bacteria enters your pet’s body again, these cells can instantly begin the immune response and prevent illness from developing at all!
So how do vaccines fit in to all of this? Simply put, they teach the immune system to recognize a certain virus or bacteria (and thus create memory cells) without actually infecting the animal with that disease. In animals this is usually done in one of two ways, with a modified live vaccine, a vaccine containing microbes which can still ‘interact’ with the body but have been edited to remove their ability to cause damage while leaving their antigens intact, or a killed vaccine, containing ‘dead’ but otherwise whole microbes. In both cases the immune system responds and is able to ‘learn’ the antigens without the body being under attack.
There are multiple reasons why a vaccine would need to be boosted (given multiple times). The first is that baby animals receive a certain degree of immunity from their mother. This immunity does wear off, but the time it takes to stop being effective varies hugely for every individual animal — and a vaccine will not work if the mother’s immunity is still present (the mother’s immune response will act rapidly, meaning that the baby’s immune system won’t have a chance to learn the antigens). This is why it is recommended to start vaccinating puppies and kittens between 6-8 weeks of age and continue monthly until they are 12 to 16 weeks old. This ensures that no matter when the mother’s immunity wears off, the baby is still getting a vaccine. But be aware! There is a time called the window of susceptibility where the mother’s immunity is too high to allow a vaccine to work but too low to effectively protect the baby, making them vulnerable to disease. This is why it’s important to keep your puppy or kitten only around fully vaccinated animals until they have had all of their boosters.
Vaccines are slightly less effective at teaching the immune system than a true infection. Boosting the vaccine gives the immune system multiple chances to learn and build a response. Immunity can also wear off over time depending on your animal’s individual response, which is why boosters either annually or every three years are recommended. Certain vaccines tend to provide less lasting immunity than others. It is possible to test your animal’s blood to determine their immune response to certain diseases and therefore know whether or not they need a vaccine; speak with your veterinarian to learn more.
Finally, it’s important to remember that there are times when vaccines will not work or are inappropriate. Animals who are immunocompromised such as those who are having chemotherapy or taking high doses of steroid may not respond properly to a vaccine and could still be vulnerable to disease. An animal which is already sick will also have difficulty mounting a proper response and should not be vaccinated (this is why if your pet comes in to the veterinarian while ill we recommend not boosting their vaccines until they are healthy again). And some animals may have allergic reactions to vaccines. This is why it is so important to vaccinate your animals if you can; by having a certain percentage of fully vaccinated and immune animals we create herd immunity, which protects vulnerable animals by not giving the disease any chance to infect and spread. Vaccination protects all pets, not just your own!
Hopefully now you have a better understanding of the immune system and the role vaccines play in protecting our pet’s health. Tune in next week for a discussion of what diseases we can and should vaccinate against!
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